Drug interactions
Apremilast + Bosentan
Severity: Moderate
Apremilast and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce apremilast exposure through CYP3A4 induction, though it is a moderate rather than strong inducer. Reduced apremilast levels may reduce control of psoriasis or psoriatic arthritis.
What this interaction means in plain words
Apremilast and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apremilast belongs to Miscellaneous; Bosentan belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by bosentan increases apremilast metabolism.
What to do
Monitor for loss of apremilast efficacy and consider an alternative therapy if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Apremilast
- Apalutamide + Apremilast Major
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Enzalutamide Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
Frequently asked questions
Can I take Apremilast with Bosentan?
MediHelp rates the interaction as moderate. Apremilast and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce apremilast exposure through CYP3A4 induction, though it is a moderate rather than strong inducer. Reduced apremilast levels may reduce control of psoriasis or psoriatic arthritis.
How serious is the interaction between Apremilast and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of apremilast efficacy and consider an alternative therapy if response declines.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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