Drug interactions
Aprepitant + Artemether / lumefantrine
Severity: Moderate
Aprepitant and Artemether / lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and artemether and lumefantrine are both CYP3A4 substrates, so their exposure may rise. Lumefantrine can prolong the QT interval, which makes higher levels potentially relevant.
What this interaction means in plain words
Aprepitant and Artemether / lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, reducing metabolism of artemether and lumefantrine.
What to do
Monitor for adverse effects, and consider ECG monitoring in patients with QT risk factors. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Artemether / lumefantrine?
MediHelp rates the interaction as moderate. Aprepitant and Artemether / lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and artemether and lumefantrine are both CYP3A4 substrates, so their exposure may rise. Lumefantrine can prolong the QT interval, which makes higher levels potentially relevant.
How serious is the interaction between Aprepitant and Artemether / lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects, and consider ECG monitoring in patients with QT risk factors. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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