Drug interactions
Aprepitant + Bazedoxifene / conjugated estrogens
Severity: Minor
Aprepitant and Bazedoxifene / conjugated estrogens: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may modestly raise exposure to the estrogen component through CYP3A4 inhibition, although short antiemetic courses make the effect small. Sustained effects are unlikely to be clinically important.
What this interaction means in plain words
Aprepitant and Bazedoxifene / conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aprepitant inhibits CYP3A4, which partly metabolizes estrogens and bazedoxifene.
What to do
No routine adjustment is needed for a short aprepitant course. Monitor for estrogenic adverse effects such as breast tenderness or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Bazedoxifene / conjugated estrogens?
MediHelp rates the interaction as minor. Aprepitant and Bazedoxifene / conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant may modestly raise exposure to the estrogen component through CYP3A4 inhibition, although short antiemetic courses make the effect small. Sustained effects are unlikely to be clinically important.
How serious is the interaction between Aprepitant and Bazedoxifene / conjugated estrogens?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for a short aprepitant course. Monitor for estrogenic adverse effects such as breast tenderness or bleeding.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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