Drug interactions
Aprepitant + Budesonide
Severity: Moderate
Aprepitant and Budesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise budesonide exposure, increasing systemic corticosteroid effects. Aprepitant is itself known to raise levels of some corticosteroids such as dexamethasone.
What this interaction means in plain words
Aprepitant and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Budesonide belongs to Respiratory.
Why it happens
Aprepitant inhibits CYP3A4, reducing the metabolism of budesonide.
What to do
Monitor for signs of corticosteroid excess such as Cushingoid features, hyperglycemia and adrenal suppression during prolonged use; limit duration where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Budesonide?
MediHelp rates the interaction as moderate. Aprepitant and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise budesonide exposure, increasing systemic corticosteroid effects. Aprepitant is itself known to raise levels of some corticosteroids such as dexamethasone.
How serious is the interaction between Aprepitant and Budesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess such as Cushingoid features, hyperglycemia and adrenal suppression during prolonged use; limit duration where possible.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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