Drug interactions
Aprepitant + Buprenorphine long-acting
Severity: Moderate
Aprepitant and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and may increase buprenorphine exposure from the long-acting injection. The depot cannot be quickly adjusted, so excess opioid effects such as sedation and respiratory depression may persist.
What this interaction means in plain words
Aprepitant and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated buprenorphine metabolism by aprepitant.
What to do
Monitor for sedation, respiratory depression and signs of buprenorphine toxicity. If these occur and aprepitant cannot be reduced or stopped, switch to a buprenorphine formulation that allows dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Aprepitant and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and may increase buprenorphine exposure from the long-acting injection. The depot cannot be quickly adjusted, so excess opioid effects such as sedation and respiratory depression may persist.
How serious is the interaction between Aprepitant and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and signs of buprenorphine toxicity. If these occur and aprepitant cannot be reduced or stopped, switch to a buprenorphine formulation that allows dose adjustment.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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