Drug interactions
Aprepitant + Butabarbital
Severity: Moderate
Aprepitant and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can lower aprepitant concentrations, which may reduce its antiemetic efficacy. The effect is expected to be clinically relevant with continued barbiturate use.
What this interaction means in plain words
Aprepitant and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butabarbital induces CYP3A4, increasing aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting, and add other antiemetics if control is poor. Consider an alternative to the barbiturate when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Butabarbital?
MediHelp rates the interaction as moderate. Aprepitant and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can lower aprepitant concentrations, which may reduce its antiemetic efficacy. The effect is expected to be clinically relevant with continued barbiturate use.
How serious is the interaction between Aprepitant and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting, and add other antiemetics if control is poor. Consider an alternative to the barbiturate when possible.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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