Drug interactions
Aprepitant + Butalbital
Severity: Moderate
Aprepitant and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that induces CYP3A4 and may lower aprepitant concentrations, potentially weakening its antiemetic effect. The impact is greatest with regular butalbital use.
What this interaction means in plain words
Aprepitant and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital induces CYP3A4, increasing aprepitant clearance.
What to do
Watch for breakthrough chemotherapy-induced nausea and vomiting and add rescue antiemetics if needed. Limit frequent butalbital use during aprepitant therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Butalbital?
MediHelp rates the interaction as moderate. Aprepitant and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that induces CYP3A4 and may lower aprepitant concentrations, potentially weakening its antiemetic effect. The impact is greatest with regular butalbital use.
How serious is the interaction between Aprepitant and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for breakthrough chemotherapy-induced nausea and vomiting and add rescue antiemetics if needed. Limit frequent butalbital use during aprepitant therapy.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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