Drug interactions
Aprepitant + Cabozantinib
Severity: Moderate
Aprepitant and Cabozantinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib is a CYP3A4 substrate, so aprepitant may increase its exposure. This could raise the risk of diarrhea, hypertension, hand-foot syndrome and other adverse effects.
What this interaction means in plain words
Aprepitant and Cabozantinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Cabozantinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing cabozantinib metabolism.
What to do
Monitor for cabozantinib toxicity, especially with repeated aprepitant courses. Reduce the cabozantinib dose if adverse effects become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Aprepitant with Cabozantinib?
MediHelp rates the interaction as moderate. Aprepitant and Cabozantinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabozantinib is a CYP3A4 substrate, so aprepitant may increase its exposure. This could raise the risk of diarrhea, hypertension, hand-foot syndrome and other adverse effects.
How serious is the interaction between Aprepitant and Cabozantinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib toxicity, especially with repeated aprepitant courses. Reduce the cabozantinib dose if adverse effects become significant.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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