Drug interactions
Aprepitant + Cannabidiol
Severity: Moderate
Aprepitant and Cannabidiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may raise cannabidiol concentrations by inhibiting CYP3A4, one of its metabolic pathways. This could increase somnolence, sedation and liver enzyme elevations.
What this interaction means in plain words
Aprepitant and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Cannabidiol belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated cannabidiol metabolism by aprepitant.
What to do
Monitor for excess sedation and adverse effects, and consider reducing the cannabidiol dose. Check liver enzymes if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Aprepitant with Cannabidiol?
MediHelp rates the interaction as moderate. Aprepitant and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may raise cannabidiol concentrations by inhibiting CYP3A4, one of its metabolic pathways. This could increase somnolence, sedation and liver enzyme elevations.
How serious is the interaction between Aprepitant and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and adverse effects, and consider reducing the cannabidiol dose. Check liver enzymes if clinically indicated.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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