Drug interactions
Aprepitant + Conivaptan
Severity: Moderate
Aprepitant and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan inhibits CYP3A4 and may increase aprepitant exposure. This could increase aprepitant adverse effects, though conivaptan is given short term by infusion.
What this interaction means in plain words
Aprepitant and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, decreasing the clearance of aprepitant.
What to do
Monitor for aprepitant adverse effects during the conivaptan infusion. Aprepitant may also raise conivaptan levels, so monitor serum sodium rise to avoid overly rapid correction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Conivaptan?
MediHelp rates the interaction as moderate. Aprepitant and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan inhibits CYP3A4 and may increase aprepitant exposure. This could increase aprepitant adverse effects, though conivaptan is given short term by infusion.
How serious is the interaction between Aprepitant and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects during the conivaptan infusion. Aprepitant may also raise conivaptan levels, so monitor serum sodium rise to avoid overly rapid correction.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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