Drug interactions
Aprepitant + Conjugated estrogens
Severity: Minor
Aprepitant and Conjugated estrogens: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may modestly increase estrogen exposure through CYP3A4 inhibition, but short antiemetic courses make a meaningful effect unlikely. Aprepitant can also reduce hormonal contraceptive efficacy, so estrogen-based contraception may need backup.
What this interaction means in plain words
Aprepitant and Conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aprepitant inhibits CYP3A4, which partly metabolizes estrogens, and may induce metabolism with prolonged use.
What to do
No routine change is needed for HRT during short aprepitant courses. Monitor for estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Conjugated estrogens?
MediHelp rates the interaction as minor. Aprepitant and Conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant may modestly increase estrogen exposure through CYP3A4 inhibition, but short antiemetic courses make a meaningful effect unlikely. Aprepitant can also reduce hormonal contraceptive efficacy, so estrogen-based contraception may need backup.
How serious is the interaction between Aprepitant and Conjugated estrogens?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for HRT during short aprepitant courses. Monitor for estrogenic adverse effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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