Drug interactions
Aprepitant + Cortisone
Severity: Moderate
Aprepitant and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant can raise systemic corticosteroid exposure through CYP3A4 inhibition, which is why oral dexamethasone doses are reduced with it. Cortisone is a weaker CYP3A4 substrate, so the effect may be smaller, but it could still increase glucocorticoid effects.
What this interaction means in plain words
Aprepitant and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, decreasing corticosteroid clearance.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and mood changes. Consider a lower steroid dose if treatment is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Cortisone?
MediHelp rates the interaction as moderate. Aprepitant and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant can raise systemic corticosteroid exposure through CYP3A4 inhibition, which is why oral dexamethasone doses are reduced with it. Cortisone is a weaker CYP3A4 substrate, so the effect may be smaller, but it could still increase glucocorticoid effects.
How serious is the interaction between Aprepitant and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and mood changes. Consider a lower steroid dose if treatment is prolonged.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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