Drug interactions
Aprepitant + Darifenacin
Severity: Moderate
Aprepitant and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is metabolized by CYP3A4 and CYP2D6, so aprepitant may increase its plasma levels. This may intensify anticholinergic effects such as dry mouth, constipation, blurred vision and urinary retention.
What this interaction means in plain words
Aprepitant and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Darifenacin belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4, reducing darifenacin clearance.
What to do
Monitor for anticholinergic adverse effects during the aprepitant course and reduce the darifenacin dose if they become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Darifenacin
Frequently asked questions
Can I take Aprepitant with Darifenacin?
MediHelp rates the interaction as moderate. Aprepitant and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darifenacin is metabolized by CYP3A4 and CYP2D6, so aprepitant may increase its plasma levels. This may intensify anticholinergic effects such as dry mouth, constipation, blurred vision and urinary retention.
How serious is the interaction between Aprepitant and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects during the aprepitant course and reduce the darifenacin dose if they become troublesome.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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