Drug interactions
Aprepitant + Deferasirox
Severity: Moderate
Aprepitant and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower aprepitant concentrations, so antiemetic efficacy could be reduced. The effect is likely modest, and the clinical consequence is mainly less effective prevention of nausea and vomiting.
What this interaction means in plain words
Aprepitant and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox may induce CYP3A4 and increase aprepitant clearance, though it is also a weak inhibitor of other pathways.
What to do
Monitor for breakthrough nausea and vomiting and add or adjust rescue antiemetics if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Aprepitant with Deferasirox?
MediHelp rates the interaction as moderate. Aprepitant and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and lower aprepitant concentrations, so antiemetic efficacy could be reduced. The effect is likely modest, and the clinical consequence is mainly less effective prevention of nausea and vomiting.
How serious is the interaction between Aprepitant and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add or adjust rescue antiemetics if control is inadequate.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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