Drug interactions
Aprepitant + Dexamethasone-tobramycin
Severity: Moderate
Aprepitant and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and raises dexamethasone exposure, while dexamethasone may modestly lower aprepitant levels through induction. Labeling recommends reducing the oral dexamethasone dose when given with aprepitant for chemotherapy-induced nausea.
What this interaction means in plain words
Aprepitant and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Aprepitant inhibits CYP3A4, reducing dexamethasone clearance; dexamethasone is a weak-to-moderate CYP3A4 inducer.
What to do
Use the reduced dexamethasone dosing recommended in antiemetic regimens containing aprepitant. Monitor for corticosteroid adverse effects and antiemetic efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Aprepitant and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and raises dexamethasone exposure, while dexamethasone may modestly lower aprepitant levels through induction. Labeling recommends reducing the oral dexamethasone dose when given with aprepitant for chemotherapy-induced nausea.
How serious is the interaction between Aprepitant and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced dexamethasone dosing recommended in antiemetic regimens containing aprepitant. Monitor for corticosteroid adverse effects and antiemetic efficacy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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