Drug interactions
Aprepitant + Dichlorphenamide
Severity: Minor
Aprepitant and Dichlorphenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss, and this is a known adverse effect. Aprepitant is not established as a potassium-lowering drug, though vomiting or other therapy in the setting of use may contribute to hypokalemia. The claimed direct additive effect is not well supported.
What this interaction means in plain words
Aprepitant and Dichlorphenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Dichlorphenamide belongs to Miscellaneous.
Why it happens
No established direct interaction; any hypokalemia would largely be due to dichlorphenamide and underlying illness.
What to do
Monitor serum potassium as per dichlorphenamide labeling, particularly if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Aprepitant with Dichlorphenamide?
MediHelp rates the interaction as minor. Aprepitant and Dichlorphenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dichlorphenamide causes potassium loss, and this is a known adverse effect. Aprepitant is not established as a potassium-lowering drug, though vomiting or other therapy in the setting of use may contribute to hypokalemia. The claimed direct additive effect is not well supported.
How serious is the interaction between Aprepitant and Dichlorphenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium as per dichlorphenamide labeling, particularly if vomiting or diarrhea occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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