Drug interactions
Aprepitant + Dienogest / estradiol valerate
Severity: Moderate
Aprepitant and Dienogest / estradiol valerate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dienogest is a CYP3A4 substrate, so aprepitant may raise exposure to the contraceptive components. Aprepitant can also lower contraceptive hormone levels with repeated dosing, so the net effect is uncertain.
What this interaction means in plain words
Aprepitant and Dienogest / estradiol valerate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, but may induce metabolism of hormones with repeated dosing.
What to do
Advise a backup non-hormonal contraceptive method during and for a period after aprepitant treatment. Monitor for hormonal adverse effects such as breast tenderness or irregular bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Dienogest / estradiol valerate?
MediHelp rates the interaction as moderate. Aprepitant and Dienogest / estradiol valerate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dienogest is a CYP3A4 substrate, so aprepitant may raise exposure to the contraceptive components. Aprepitant can also lower contraceptive hormone levels with repeated dosing, so the net effect is uncertain.
How serious is the interaction between Aprepitant and Dienogest / estradiol valerate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise a backup non-hormonal contraceptive method during and for a period after aprepitant treatment. Monitor for hormonal adverse effects such as breast tenderness or irregular bleeding.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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