Drug interactions
Aprepitant + Diltiazem
Severity: Moderate
Aprepitant and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and raises aprepitant concentrations. Aprepitant may in turn increase diltiazem levels, with a risk of hypotension and bradycardia.
What this interaction means in plain words
Aprepitant and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Diltiazem belongs to Cardiovascular.
Why it happens
Mutual inhibition of CYP3A4 metabolism by the two drugs.
What to do
Monitor blood pressure and heart rate, and watch for aprepitant adverse effects. Adjust the diltiazem dose if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Aprepitant with Diltiazem?
MediHelp rates the interaction as moderate. Aprepitant and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor and raises aprepitant concentrations. Aprepitant may in turn increase diltiazem levels, with a risk of hypotension and bradycardia.
How serious is the interaction between Aprepitant and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and watch for aprepitant adverse effects. Adjust the diltiazem dose if hypotension or bradycardia develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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