Drug interactions
Aprepitant + Doxorubicin liposomal
Severity: Minor
Aprepitant and Doxorubicin liposomal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is partly metabolized through CYP3A4, but liposomal encapsulation changes its disposition and the interaction is poorly characterized. Any increase in exposure is likely small.
What this interaction means in plain words
Aprepitant and Doxorubicin liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aprepitant inhibits CYP3A4, which could modestly reduce doxorubicin metabolism.
What to do
No dose change is required. Monitor for increased myelosuppression and cardiotoxicity as routinely done during doxorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Doxorubicin liposomal?
MediHelp rates the interaction as minor. Aprepitant and Doxorubicin liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is partly metabolized through CYP3A4, but liposomal encapsulation changes its disposition and the interaction is poorly characterized. Any increase in exposure is likely small.
How serious is the interaction between Aprepitant and Doxorubicin liposomal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor for increased myelosuppression and cardiotoxicity as routinely done during doxorubicin therapy.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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