Drug interactions
Aprepitant + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Aprepitant and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A inhibitor and can substantially increase aprepitant concentrations. This may increase aprepitant adverse effects such as fatigue, dizziness and gastrointestinal upset. Aprepitant's own CYP3A effects on the antiretroviral are less certain.
What this interaction means in plain words
Aprepitant and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects. For single-dose antiemetic use the combination is usually manageable, while prolonged regimens warrant closer review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Aprepitant and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A inhibitor and can substantially increase aprepitant concentrations. This may increase aprepitant adverse effects such as fatigue, dizziness and gastrointestinal upset. Aprepitant's own CYP3A effects on the antiretroviral are less certain.
How serious is the interaction between Aprepitant and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects. For single-dose antiemetic use the combination is usually manageable, while prolonged regimens warrant closer review.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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