Drug interactions
Aprepitant + Estradiol vaginal
Severity: Minor
Aprepitant and Estradiol vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estradiol is partly metabolized by CYP3A4, but low-dose vaginal products produce small systemic exposure. Any increase from aprepitant is unlikely to be clinically meaningful.
What this interaction means in plain words
Aprepitant and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by aprepitant could slightly reduce estradiol metabolism.
What to do
No action is generally required. Be aware of estrogenic adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Estradiol vaginal?
MediHelp rates the interaction as minor. Aprepitant and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estradiol is partly metabolized by CYP3A4, but low-dose vaginal products produce small systemic exposure. Any increase from aprepitant is unlikely to be clinically meaningful.
How serious is the interaction between Aprepitant and Estradiol vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Be aware of estrogenic adverse effects if symptoms arise.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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