Drug interactions
Aprepitant + Estrogens conjugated synthetic
Severity: Minor
Aprepitant and Estrogens conjugated synthetic: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may modestly alter exposure to synthetic conjugated estrogens through its CYP3A4 effects, but short antiemetic courses make this unlikely to matter. The effect on hormonal therapy is probably small.
What this interaction means in plain words
Aprepitant and Estrogens conjugated synthetic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aprepitant inhibits CYP3A4, which partly metabolizes estrogens.
What to do
No routine adjustment is needed. Monitor for estrogenic adverse effects or loss of symptom control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Estrogens conjugated synthetic, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Estrogens conjugated synthetic?
MediHelp rates the interaction as minor. Aprepitant and Estrogens conjugated synthetic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant may modestly alter exposure to synthetic conjugated estrogens through its CYP3A4 effects, but short antiemetic courses make this unlikely to matter. The effect on hormonal therapy is probably small.
How serious is the interaction between Aprepitant and Estrogens conjugated synthetic?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for estrogenic adverse effects or loss of symptom control.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
