Drug interactions
Aprepitant + Estropipate
Severity: Minor
Aprepitant and Estropipate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and may modestly raise exposure to estrogens that are partly cleared by CYP3A4. Clinically this is unlikely to be significant, but estrogenic effects could be somewhat increased.
What this interaction means in plain words
Aprepitant and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aprepitant inhibits CYP3A4, which contributes to estrogen metabolism, reducing clearance of estropipate.
What to do
No routine dose change is needed; watch for estrogen adverse effects such as breast tenderness or fluid retention if aprepitant is used repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Estropipate?
MediHelp rates the interaction as minor. Aprepitant and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor and may modestly raise exposure to estrogens that are partly cleared by CYP3A4. Clinically this is unlikely to be significant, but estrogenic effects could be somewhat increased.
How serious is the interaction between Aprepitant and Estropipate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for estrogen adverse effects such as breast tenderness or fluid retention if aprepitant is used repeatedly.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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