Drug interactions
Aprepitant + Etoposide
Severity: Minor
Aprepitant and Etoposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is partly metabolized by CYP3A4, so aprepitant may modestly raise its exposure. Studies have not shown a major clinical change, but toxicity such as myelosuppression could theoretically increase.
What this interaction means in plain words
Aprepitant and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Etoposide belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4 and may reduce etoposide clearance.
What to do
Monitor blood counts as routine in chemotherapy and no dose adjustment is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Aprepitant with Etoposide?
MediHelp rates the interaction as minor. Aprepitant and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etoposide is partly metabolized by CYP3A4, so aprepitant may modestly raise its exposure. Studies have not shown a major clinical change, but toxicity such as myelosuppression could theoretically increase.
How serious is the interaction between Aprepitant and Etoposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts as routine in chemotherapy and no dose adjustment is usually required.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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