Drug interactions
Aprepitant + Grapefruit
Severity: Minor
Aprepitant and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may increase aprepitant exposure. The clinical consequence is likely small, with possible increase in aprepitant adverse effects.
What this interaction means in plain words
Aprepitant and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4, reducing first-pass metabolism of aprepitant.
What to do
Advise patients to avoid large amounts of grapefruit juice around aprepitant dosing days. No dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Grapefruit?
MediHelp rates the interaction as minor. Aprepitant and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may increase aprepitant exposure. The clinical consequence is likely small, with possible increase in aprepitant adverse effects.
How serious is the interaction between Aprepitant and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid large amounts of grapefruit juice around aprepitant dosing days. No dose adjustment is needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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