Drug interactions
Aprepitant + Griseofulvin
Severity: Moderate
Aprepitant and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin induces CYP3A4 and may reduce aprepitant concentrations. This could lower antiemetic effectiveness, particularly with prolonged griseofulvin use.
What this interaction means in plain words
Aprepitant and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Griseofulvin belongs to Anti Fungals.
Why it happens
Griseofulvin induces CYP3A4, increasing aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting and add rescue antiemetics as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Aprepitant with Griseofulvin?
MediHelp rates the interaction as moderate. Aprepitant and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin induces CYP3A4 and may reduce aprepitant concentrations. This could lower antiemetic effectiveness, particularly with prolonged griseofulvin use.
How serious is the interaction between Aprepitant and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add rescue antiemetics as needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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