Drug interactions
Aprepitant + Hydrocortisone
Severity: Minor
Aprepitant and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may increase hydrocortisone exposure via CYP3A4 inhibition, with possible increased corticosteroid effects. Hydrocortisone is not a strong inducer, so any reduction in aprepitant levels is likely small.
What this interaction means in plain words
Aprepitant and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Hydrocortisone belongs to Endocrine.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of hydrocortisone.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention; adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Aprepitant with Hydrocortisone?
MediHelp rates the interaction as minor. Aprepitant and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant may increase hydrocortisone exposure via CYP3A4 inhibition, with possible increased corticosteroid effects. Hydrocortisone is not a strong inducer, so any reduction in aprepitant levels is likely small.
How serious is the interaction between Aprepitant and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention; adjust the dose if needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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