Drug interactions
Aprepitant + Hydroxyprogesterone caproate
Severity: Minor
Aprepitant and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is metabolized partly by CYP3A4, so aprepitant could modestly raise its levels. The effect is expected to be small and short-lived with usual aprepitant courses.
What this interaction means in plain words
Aprepitant and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Aprepitant inhibits CYP3A4, reducing hydroxyprogesterone caproate clearance.
What to do
No dose adjustment is needed; be aware of possible increased progestogen effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Aprepitant and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is metabolized partly by CYP3A4, so aprepitant could modestly raise its levels. The effect is expected to be small and short-lived with usual aprepitant courses.
How serious is the interaction between Aprepitant and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of possible increased progestogen effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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