Drug interactions
Aprepitant + Indinavir
Severity: Moderate
Aprepitant and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and substantially increases aprepitant exposure, while aprepitant may modestly increase indinavir levels. This can increase aprepitant adverse effects and possibly protease inhibitor toxicity.
What this interaction means in plain words
Aprepitant and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual CYP3A4 inhibition, with indinavir strongly reducing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects and indinavir toxicity such as nephrolithiasis. Use the shortest aprepitant regimen needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Indinavir?
MediHelp rates the interaction as moderate. Aprepitant and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor and substantially increases aprepitant exposure, while aprepitant may modestly increase indinavir levels. This can increase aprepitant adverse effects and possibly protease inhibitor toxicity.
How serious is the interaction between Aprepitant and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects and indinavir toxicity such as nephrolithiasis. Use the shortest aprepitant regimen needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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