Drug interactions
Aprepitant + Irinotecan liposomal
Severity: Moderate
Aprepitant and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan and its active metabolite SN-38 are affected by CYP3A4, and inhibition could raise exposure to toxic metabolites. Aprepitant has not been shown to significantly change irinotecan exposure, but the potential for increased neutropenia and diarrhea exists.
What this interaction means in plain words
Aprepitant and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, which may shift irinotecan metabolism, though clinical effect is not well established.
What to do
Monitor blood counts and diarrhea during chemotherapy. No empiric dose change is recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Aprepitant and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan and its active metabolite SN-38 are affected by CYP3A4, and inhibition could raise exposure to toxic metabolites. Aprepitant has not been shown to significantly change irinotecan exposure, but the potential for increased neutropenia and diarrhea exists.
How serious is the interaction between Aprepitant and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea during chemotherapy. No empiric dose change is recommended.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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