Drug interactions
Aprepitant + Isradipine
Severity: Moderate
Aprepitant and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is a CYP3A4 substrate, and aprepitant may increase its exposure. This can cause excessive hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Aprepitant and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by aprepitant decreases isradipine first-pass and systemic metabolism.
What to do
Monitor blood pressure and heart rate, and reduce the isradipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Isradipine?
MediHelp rates the interaction as moderate. Aprepitant and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isradipine is a CYP3A4 substrate, and aprepitant may increase its exposure. This can cause excessive hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Aprepitant and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reduce the isradipine dose if hypotension or edema occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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