Drug interactions
Aprepitant + Ixabepilone
Severity: Moderate
Aprepitant and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is cleared mainly by CYP3A4, and moderate inhibitors can raise exposure and toxicity such as neutropenia and neuropathy. Aprepitant may therefore increase ixabepilone effects.
What this interaction means in plain words
Aprepitant and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, decreasing ixabepilone metabolism.
What to do
Monitor blood counts and neurotoxicity closely; consider an alternative antiemetic if toxicity is a concern. Dose reduction of ixabepilone is advised with strong inhibitors, and caution applies with moderate ones.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Ixabepilone?
MediHelp rates the interaction as moderate. Aprepitant and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is cleared mainly by CYP3A4, and moderate inhibitors can raise exposure and toxicity such as neutropenia and neuropathy. Aprepitant may therefore increase ixabepilone effects.
How serious is the interaction between Aprepitant and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity closely; consider an alternative antiemetic if toxicity is a concern. Dose reduction of ixabepilone is advised with strong inhibitors, and caution applies with moderate ones.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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