Drug interactions
Aprepitant + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Moderate
Aprepitant and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant can lower hormonal contraceptive exposure, possibly through weak CYP3A4 and CYP2C9 induction during and shortly after the treatment course. Contraceptive efficacy could be reduced.
What this interaction means in plain words
Aprepitant and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant induces hepatic metabolism of ethinylestradiol and progestins, lowering hormone levels.
What to do
Use an additional non-hormonal contraceptive method during aprepitant treatment and for about one month after the last dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as moderate. Aprepitant and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant can lower hormonal contraceptive exposure, possibly through weak CYP3A4 and CYP2C9 induction during and shortly after the treatment course. Contraceptive efficacy could be reduced.
How serious is the interaction between Aprepitant and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional non-hormonal contraceptive method during aprepitant treatment and for about one month after the last dose.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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