Drug interactions
Aprepitant + Lumefantrine
Severity: Moderate
Aprepitant and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is metabolized by CYP3A4 and prolongs the QT interval. Aprepitant may raise lumefantrine exposure and thereby QT risk.
What this interaction means in plain words
Aprepitant and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, reducing lumefantrine metabolism.
What to do
Monitor ECG and electrolytes if other QT-prolonging drugs or risk factors are present. Watch for adverse effects during overlap.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Lumefantrine?
MediHelp rates the interaction as moderate. Aprepitant and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is metabolized by CYP3A4 and prolongs the QT interval. Aprepitant may raise lumefantrine exposure and thereby QT risk.
How serious is the interaction between Aprepitant and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if other QT-prolonging drugs or risk factors are present. Watch for adverse effects during overlap.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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