Drug interactions
Aprepitant + Marijuana
Severity: Minor
Aprepitant and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids are weak inhibitors of CYP3A4 in vitro and might slightly raise aprepitant levels. The clinical relevance is unclear and probably small.
What this interaction means in plain words
Aprepitant and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cannabinoids may inhibit CYP3A4 in vitro; clinical significance is not established.
What to do
No action beyond awareness; monitor for increased sedation or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Marijuana?
MediHelp rates the interaction as minor. Aprepitant and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids are weak inhibitors of CYP3A4 in vitro and might slightly raise aprepitant levels. The clinical relevance is unclear and probably small.
How serious is the interaction between Aprepitant and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness; monitor for increased sedation or dizziness.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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