Drug interactions
Aprepitant + Mestranol
Severity: Moderate
Aprepitant and Mestranol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol is metabolized to ethinylestradiol, which is partly cleared by CYP3A4. Aprepitant can reduce hormonal contraceptive efficacy through enzyme induction with repeated dosing, so contraceptive reliability may fall.
What this interaction means in plain words
Aprepitant and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant has mixed CYP3A4 inhibitory and inductive effects that may alter estrogen exposure and lower contraceptive exposure.
What to do
Advise an additional non-hormonal contraceptive method during aprepitant use and for about one month afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Mestranol?
MediHelp rates the interaction as moderate. Aprepitant and Mestranol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mestranol is metabolized to ethinylestradiol, which is partly cleared by CYP3A4. Aprepitant can reduce hormonal contraceptive efficacy through enzyme induction with repeated dosing, so contraceptive reliability may fall.
How serious is the interaction between Aprepitant and Mestranol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during aprepitant use and for about one month afterwards.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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