Drug interactions
Aprepitant + Metronidazole
Severity: Minor
Aprepitant and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is not a clinically meaningful CYP3A4 inhibitor, so a significant rise in aprepitant levels is not expected. No relevant interaction is established.
What this interaction means in plain words
Aprepitant and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Metronidazole belongs to Anti Parasitic.
Why it happens
No established mechanism; at most a weak CYP3A4 effect.
What to do
No action beyond routine monitoring of aprepitant tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Aprepitant with Metronidazole?
MediHelp rates the interaction as minor. Aprepitant and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is not a clinically meaningful CYP3A4 inhibitor, so a significant rise in aprepitant levels is not expected. No relevant interaction is established.
How serious is the interaction between Aprepitant and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond routine monitoring of aprepitant tolerability.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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