Drug interactions
Aprepitant + Nitrendipine
Severity: Moderate
Aprepitant and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine undergoes extensive CYP3A4 metabolism, so aprepitant may increase its levels. This can lead to hypotension, reflex tachycardia, headache and edema.
What this interaction means in plain words
Aprepitant and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by aprepitant reduces nitrendipine metabolism.
What to do
Monitor blood pressure and adjust the nitrendipine dose if excessive hypotension or adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Nitrendipine?
MediHelp rates the interaction as moderate. Aprepitant and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrendipine undergoes extensive CYP3A4 metabolism, so aprepitant may increase its levels. This can lead to hypotension, reflex tachycardia, headache and edema.
How serious is the interaction between Aprepitant and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the nitrendipine dose if excessive hypotension or adverse effects develop.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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