Drug interactions
Aprepitant + Paclitaxel protein bound
Severity: Moderate
Aprepitant and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared by CYP2C8 and CYP3A4, so aprepitant could modestly raise exposure. This may increase myelosuppression and neuropathy, although the effect appears limited.
What this interaction means in plain words
Aprepitant and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by aprepitant may reduce a secondary pathway of paclitaxel metabolism.
What to do
Monitor blood counts and neuropathy, and adjust paclitaxel dose per standard toxicity-based criteria.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Aprepitant and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is cleared by CYP2C8 and CYP3A4, so aprepitant could modestly raise exposure. This may increase myelosuppression and neuropathy, although the effect appears limited.
How serious is the interaction between Aprepitant and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and adjust paclitaxel dose per standard toxicity-based criteria.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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