Drug interactions
Aprepitant + Parecoxib
Severity: Minor
Aprepitant and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is a prodrug converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9. Aprepitant may raise valdecoxib levels, but this is unlikely to be clinically important in short perioperative use.
What this interaction means in plain words
Aprepitant and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by aprepitant may reduce valdecoxib metabolism.
What to do
No dose change is usually needed. Monitor for NSAID adverse effects such as renal impairment or hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Parecoxib?
MediHelp rates the interaction as minor. Aprepitant and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is a prodrug converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9. Aprepitant may raise valdecoxib levels, but this is unlikely to be clinically important in short perioperative use.
How serious is the interaction between Aprepitant and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for NSAID adverse effects such as renal impairment or hypertension.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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