Drug interactions
Aprepitant + Pentobarbital
Severity: Moderate
Aprepitant and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is a CYP3A4 inducer and can lower aprepitant concentrations, potentially reducing its antiemetic efficacy. Barbiturates also add sedation, though that is not specific to this interaction.
What this interaction means in plain words
Aprepitant and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases aprepitant metabolism.
What to do
Monitor for breakthrough nausea and vomiting and consider additional antiemetic agents. Avoid prolonged coadministration where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Pentobarbital?
MediHelp rates the interaction as moderate. Aprepitant and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital is a CYP3A4 inducer and can lower aprepitant concentrations, potentially reducing its antiemetic efficacy. Barbiturates also add sedation, though that is not specific to this interaction.
How serious is the interaction between Aprepitant and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and consider additional antiemetic agents. Avoid prolonged coadministration where possible.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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