Drug interactions
Aprepitant + Quinupristin / dalfopristin
Severity: Moderate
Aprepitant and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise aprepitant concentrations. Because aprepitant is typically given for short courses, the clinical impact is probably modest but adverse effects such as fatigue, dizziness or GI upset may increase.
What this interaction means in plain words
Aprepitant and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects such as somnolence, dizziness and hepatic enzyme elevation. No empiric dose change is generally needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Aprepitant and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise aprepitant concentrations. Because aprepitant is typically given for short courses, the clinical impact is probably modest but adverse effects such as fatigue, dizziness or GI upset may increase.
How serious is the interaction between Aprepitant and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects such as somnolence, dizziness and hepatic enzyme elevation. No empiric dose change is generally needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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