Drug interactions
Aprepitant + Romidepsin
Severity: Moderate
Aprepitant and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is metabolized mainly by CYP3A4, so aprepitant may increase its exposure. Higher romidepsin levels could increase toxicities such as myelosuppression, nausea and ECG changes.
What this interaction means in plain words
Aprepitant and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, reducing romidepsin metabolism.
What to do
Monitor blood counts, electrolytes and ECG for QT changes during coadministration. Consider alternative antiemetics if toxicity is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Romidepsin?
MediHelp rates the interaction as moderate. Aprepitant and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is metabolized mainly by CYP3A4, so aprepitant may increase its exposure. Higher romidepsin levels could increase toxicities such as myelosuppression, nausea and ECG changes.
How serious is the interaction between Aprepitant and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, electrolytes and ECG for QT changes during coadministration. Consider alternative antiemetics if toxicity is a concern.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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