Drug interactions
Aprepitant + Tezacaftor
Severity: Moderate
Aprepitant and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise tezacaftor exposure, which is cleared mainly by CYP3A. Higher exposure may increase the risk of adverse effects of the cystic fibrosis regimen.
What this interaction means in plain words
Aprepitant and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by aprepitant reduces the metabolism of tezacaftor.
What to do
Reduce the tezacaftor/ivacaftor dosing frequency as directed in the product labeling for moderate CYP3A inhibitors. Monitor for adverse effects during and after aprepitant courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Tezacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Tezacaftor?
MediHelp rates the interaction as moderate. Aprepitant and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise tezacaftor exposure, which is cleared mainly by CYP3A. Higher exposure may increase the risk of adverse effects of the cystic fibrosis regimen.
How serious is the interaction between Aprepitant and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the tezacaftor/ivacaftor dosing frequency as directed in the product labeling for moderate CYP3A inhibitors. Monitor for adverse effects during and after aprepitant courses.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
