Drug interactions
Aprepitant + Theophylline
Severity: Minor
Aprepitant and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant has been reported to have limited effect on theophylline, which is mainly metabolized by CYP1A2 with CYP3A4 and CYP2E1 as minor pathways. A clinically relevant rise in theophylline levels is not expected.
What this interaction means in plain words
Aprepitant and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Theophylline belongs to Respiratory.
Why it happens
Aprepitant is a moderate CYP3A4 inhibitor, but CYP3A4 is a minor route for theophylline.
What to do
No routine adjustment is needed; monitor for theophylline toxicity if symptoms such as nausea, tremor or tachycardia occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Theophylline?
MediHelp rates the interaction as minor. Aprepitant and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant has been reported to have limited effect on theophylline, which is mainly metabolized by CYP1A2 with CYP3A4 and CYP2E1 as minor pathways. A clinically relevant rise in theophylline levels is not expected.
How serious is the interaction between Aprepitant and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for theophylline toxicity if symptoms such as nausea, tremor or tachycardia occur.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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