Drug interactions
Aprepitant + Topiramate
Severity: Minor
Aprepitant and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak to moderate CYP3A4 inducer at higher doses and could lower aprepitant concentrations. This might reduce antiemetic efficacy, although the clinical effect has not been well characterized.
What this interaction means in plain words
Aprepitant and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Topiramate belongs to Central Nervous System.
Why it happens
Topiramate may weakly induce CYP3A4, increasing aprepitant metabolism.
What to do
No dose change is required; monitor for breakthrough nausea and vomiting and add other antiemetics if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Topiramate
Frequently asked questions
Can I take Aprepitant with Topiramate?
MediHelp rates the interaction as minor. Aprepitant and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topiramate is a weak to moderate CYP3A4 inducer at higher doses and could lower aprepitant concentrations. This might reduce antiemetic efficacy, although the clinical effect has not been well characterized.
How serious is the interaction between Aprepitant and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor for breakthrough nausea and vomiting and add other antiemetics if needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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