Drug interactions
Aprepitant + Triamcinolone acetonide injectable
Severity: Moderate
Aprepitant and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamcinolone is cleared by CYP3A4, and aprepitant may increase corticosteroid exposure. With depot injections, this may prolong systemic effects such as adrenal suppression, hyperglycemia and Cushingoid features.
What this interaction means in plain words
Aprepitant and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aprepitant inhibits CYP3A4, decreasing triamcinolone clearance.
What to do
Monitor for systemic corticosteroid effects including glucose elevation and fluid retention. Consider a lower corticosteroid dose if prolonged exposure is likely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Aprepitant and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamcinolone is cleared by CYP3A4, and aprepitant may increase corticosteroid exposure. With depot injections, this may prolong systemic effects such as adrenal suppression, hyperglycemia and Cushingoid features.
How serious is the interaction between Aprepitant and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects including glucose elevation and fluid retention. Consider a lower corticosteroid dose if prolonged exposure is likely.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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