Drug interactions
Aprepitant + Zaleplon
Severity: Minor
Aprepitant and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zaleplon is metabolised mainly by aldehyde oxidase with a smaller CYP3A4 contribution. Aprepitant may modestly raise zaleplon levels, with a slight increase in sedation. The effect is unlikely to be clinically important.
What this interaction means in plain words
Aprepitant and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Zaleplon belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, the minor metabolic pathway of zaleplon.
What to do
No dose change is usually needed. Advise patients to be aware of additional drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Aprepitant with Zaleplon?
MediHelp rates the interaction as minor. Aprepitant and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zaleplon is metabolised mainly by aldehyde oxidase with a smaller CYP3A4 contribution. Aprepitant may modestly raise zaleplon levels, with a slight increase in sedation. The effect is unlikely to be clinically important.
How serious is the interaction between Aprepitant and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Advise patients to be aware of additional drowsiness.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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