Drug interactions
Aprepitant + Zanubrutinib
Severity: Moderate
Aprepitant and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant raises zanubrutinib exposure through CYP3A4 inhibition. This may increase the risk of hematologic toxicity, bleeding, infection and other adverse effects.
What this interaction means in plain words
Aprepitant and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Zanubrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by aprepitant decreases the first-pass and systemic metabolism of zanubrutinib.
What to do
Reduce zanubrutinib to the labeled dose for moderate CYP3A inhibitors and monitor blood counts and for bleeding or infection. Resume the usual dose after aprepitant is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Aprepitant with Zanubrutinib?
MediHelp rates the interaction as moderate. Aprepitant and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant raises zanubrutinib exposure through CYP3A4 inhibition. This may increase the risk of hematologic toxicity, bleeding, infection and other adverse effects.
How serious is the interaction between Aprepitant and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to the labeled dose for moderate CYP3A inhibitors and monitor blood counts and for bleeding or infection. Resume the usual dose after aprepitant is stopped.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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