Drug interactions
Aprepitant + Zolpidem
Severity: Minor
Aprepitant and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolpidem is metabolised mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Zolpidem exposure may increase, leading to more sedation, next-day impairment or complex sleep behaviours. The effect is usually modest.
What this interaction means in plain words
Aprepitant and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Zolpidem belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4, reducing the first-pass and systemic metabolism of zolpidem.
What to do
Use the lowest effective zolpidem dose and warn the patient about increased sedation. Reduce the dose if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Aprepitant with Zolpidem?
MediHelp rates the interaction as minor. Aprepitant and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zolpidem is metabolised mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Zolpidem exposure may increase, leading to more sedation, next-day impairment or complex sleep behaviours. The effect is usually modest.
How serious is the interaction between Aprepitant and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolpidem dose and warn the patient about increased sedation. Reduce the dose if excessive drowsiness occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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